Page 58 - phytochemistry general program

Nalorphine Naloxone

are commonly used narcotic antagonist drugs which are competitive
antagonists that bind to the opioid receptors with higher affinity than agonists but
do not activate the receptors. This effectively blocks the receptor, preventing the

body from responding to opiates.

NMe
H

OMe O OMe
H

Thebaine Codeine

OpiuCm22Ha2l3kNaOl7oids 413.4
O
Me O MeO

O N O NMe N
MeO Me MeO H
MeO
C=O

H

COOH MeO

O

OMe MeO OMe

Narceine MeO O

OMe Noscpine Papaverine

Tropane alkaloids

Tropane alkaloids are a well-recognized group of structurally related natural .1
products. The tropane alkaloids occur mainly in the plant family Solanaceae,

but are also found in other families e.g. convolvulaceae, Erythroxylaceae,
Discoriaceae and Amarylidaceae. Tropane nucleus consists of seven-

membered bicyclic ring with a nitrogenous bridge between C-1 and C-5.
Although it contains TWO asymmetric carbons (1&5) yet it is optically

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