Page 59 - phytochemistry general program

inactive due to internal (or intramolecular) compensation. .2
Tropane alkaloids are ester alkaloids which on hydrolysis yield an organic
acid and an amino alcohol as a base. Tropane, the parent base of the
alkaloids, consists of seven membered bicyclic ring with a nitrogenous

bridge between C1 & C5.

Me

N 2

1 3H
H
5 4
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Tropane nucleus

The major tropane alkaloids of pharmacological and therapeutic importance
can be classified into two main groups.

I- Solanaceous tropane alkaloids.

II- Coca alkaloids.

I- Solanaceous tropane alkaloids

The term solanaceous alkaloids is generally restricted to the alkaloids of the
tropane nucleus, although a number of some genera of the family Solanaceae
contain non-tropane alkaloids e.g. capsaicine, solanine, nicotine etc. Because of
their mydriatic effect, the tropane solanaceous alkaloids are also referred to as

“mydriatic alkaloids”.
Plant source

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