Page 63 - phytochemistry general program

Homatropine (Mandelyl tropine) .3

It is a synthetic alkaloid. It is prepared by passing hydrogen chloride

gas for 3-4 hours through a mixture of 7 parts of tropine, 10 parts of mandelic acid

and 2 parts of water. Homatropine is freely soluble in ether and chloroform.
Homatropine gives +ve reaction with Gerrard’s test giving red colour while with

Vitali’s test it gives yellow colour (instead of violet)

Homatropine resembles atropine and hyoscyamine in its general
physiological effects, but is much less toxic, and in small doses it exerts a hypnotic
effect. It has mydriatic effect like atropine but its action is more rapid, weaker, and

less prolonged than atropine.

Ipratropium (Isopropyl atopine) .4
It is a tropane alkaloid with quaternary nitrogen. It is used for treating

bronchial asthma and COPD.

Ipratropium .5

Atropine methobromide
It is used as antispasmodic.

Atropine methonitrate .6
It is used as antispasmodic.

Homatropine methyl bromide .7
It is used orally similar to atropine, i:e reduce over secretion & relief

gastroinestinal spasm.

Hyoscine (Scopolamine) .8

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