Page 104 - Community pharmcy practice E-book 2025
P. 104
02/11/2025, 00:29
Four pathophysiologic processes have been identified in contributing to the formation
of acne lesions:
1. Androgen-driven increase in sebum production
2. Abnormal epithelial cell desquamation & keratinocyte proliferation (follicular
hyperkeratinization)
3. Follicular colonization (proliferation of Cutibacterium acnes)
4. Inflammatory mediators
Risk and Triggering Factors
In addition to the pathophysiology of this condition, genetics, diet, and gender play
important contributory roles
Genetic factor (family history) play a role in Acne Gender !!!??
Diet (fatty and high glycemic food)
Medications (Drug induced Acne) Stress
(increase cortisol level)
Hot and humid conditions
Local irritation or friction (occlusive clothing or repeated scrubbing) Use of
oil-based skin and hair products
Prolonged sweating
Drug Induced Acne
✓ Testosterone use and Anabolics
✓ Systemic corticosteroids
✓ Less common: Antiepileptics (phenytoin), cobalt (vitamin B12), Lithium
✓ Onset is abrupt at 2 to 6 weeks after initiation of therapy
Types of Acne Vulgaris and Severity
NON-Inflammatory Lesions (Comedones)
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