Page 107 - Community pharmcy practice E-book 2025

02/11/2025, 00:29

Self-Management for Mild Acne

1. OTC Topical Vitamin A Analogues (Retinoids)

Adapalene (0.1%) is the only FDA approved OTC retinoid for mild acne treatment.

2. Keratolytics (OTC)

Benzoyl peroxide (BP) 2.5-10%
Hydroxy acids in various strengths (AHAs, BHAs) Salicylic
acid (BHA) 0.5-2%
Sulphur 3%–10%
Azelaic acid 15% (Dicarboxylic acid)

Vitamin A Analogues (Retinoids)

Topical Adapalene (Adapalene) ® in the 0.1% gel strength is the only FDA- approved
OTC retinoid
Retinol and retinal are considered cosmetic ingredients found in OTC skincare products

Adapalene is the first choice for both treatment and maintenance therapy, as it is
effective and less irritating than other topical retinoids.
How adapalene work as anti-acne product?

That promote/normalize cell turnover which leads to the unblocking of pores and the
shedding of dead skin cells
It also reduce inflammation, making them effective for mild-to-moderate acne
Patient Counseling & Precautions for Adapalene Use:
Redness, itching, dryness, scaling, and burning are common adverse effects that tend to
diminish after the first month of treatment
To avoid possible excessive irritation, avoid contact of adapalene with eyes, lips, mouth,
and nose, as well as cuts, scrapes, and other abrasions
Acne may worsen temporarily after beginning treatment with adapalene Do not
use adapalene if you have very sensitive skin
Because adapalene increases susceptibility to sunburn, avoid unnecessary sun
exposure and use a broad-spectrum sunscreen with an SPF of 15 or higher when using
this product

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