Page 53 - Community pharmcy practice E-book 2025

01/11/2025, 22:08 Medication Errors & Constipation Management

Abdominal discomfort and bloating

Incomplete defecation

Decreased appetite

Low back pain

Etiology: Constipation is Multifactorial

Common Causes Disease-Induced Constipation

Medical conditions (disease-induced) Metabolic: Diabetes, Hypokalemia,
Medications (Drug-induced) hypomagnesemia
Psychologic conditions
Physiologic conditions Endocrine: Hypothyroidism
Lifestyle factors
Neurologic & muscular: Parkinson's
disease, depression, Tumors

Disorders in large intestine, rectum
& anus: Colonic inertia, IBS, Anal
fissures, Anal fistula, ulcers,
hemorrhoidal veins

Drug-Induced Constipation

Narcotic pain medications such as codeine, oxycodone and hydromorphone
Antidepressants such as amitriptyline and imipramine
Anticonvulsants such as phenytoin and carbamazepine (Tegretol®)
Iron supplements
Calcium channel blocking drugs such as diltiazem and nifedipine
Aluminum-containing antacids (Aluminum hydroxide and Calcium Carbonate)
Drugs with anticholinergic activity
Some NSAID, antihistamines

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