Page 55 - Phytochemistry 2 (06-PG 605)
P. 55
Naloxone and Nalorphine
are commonly used narcotic antagonist drugs which are competitive
antagonists that bind to the opioid receptors with higher affinity than agonists
but do not activate the receptors. This effectively blocks the receptor, preventing
the body from responding to opiates
NMe
H
OMe O OMe
H
Thebaine Codeine
O O MeO
O Me O NMe N
MeO N MeO H
Me
MeO
C=O H MeO
COOH O
OMe MeO O OMe
OMe MeO Papaverine
54
