Page 52 - Phytochemistry 2 (06-PG 605)
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Codeine
Properties ≠ morphine
- Codeine is the methyl ether of morphine,
- Codeine differs from morphine in its solubility behavior, being soluble in water,
ether, benzene, chloroform, in ethanol .
- It does not form phenates with alkalies (as it is non phenolic) and gives no colour
with ferric chloride.
However it remains dissolved in aqueous phase after alkalinization, with either
fixed alkalis or ammonia, as the alkaloid base is water soluble
Assay : By non aqueous titration
Uses : Codeine is used to relief dry initiating cough.
Papaveratum
is a preparation containing Hydrochlorides of mixed opium alkaloids.
Noscapine was removed from the BP formulation due to
the genotoxic potential of noscapine.
Papaveratrum has analgesic and narcotic properties of morphine and is
used in the treatment of moderate and severe pain and for pre-operative
sedation usually in conjunction with hyoscine.
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