Page 50 - Phytochemistry 2 (06-PG 605)

• It contains 2 OH groups, one is a phenolic at C-3 (gives a soluble phenate
with fixed alkali) and the other is a 2ry alcoholic at C-6.

• It precipitates from its acidic solution by addition of NH4OH, NH4Cl or
(NH4)2SO4 solutions.

• On methylation of the phenolic OH groupcodeine.
• On heating with HC1  apomorphine (used as emetic).
• On acetylation  diacetylmorphine (heroine).

Apomorphine
• when morphine is heated at 140C under pressure (in a sealed tube) with

HCl, apomorphine is formed. It is a semisynthetic alkaloid

Heroine
• On acetylation of morphine it gives diacetylmorphine (heroine).

• It is of higher lipid solubility thanMorphine ,so penetrate CNS more rapidly

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