Page 85 - Phytochemistry 2 (06-PG 605)

Other Related Simple Tryptamine Derivatives
Melatonin:

H3CO H2 H2 NH
C C

N OC CH3

H

It is (N-acetyl-5-methoxytryptamine). It is a hormone, naturally
occurring in most animals, including humans, and some other
living organisms, including algae. Circulating levels vary in a daily
cycle, and melatonin is important in the regulation of the day hour's
variations of several biological functions.

Ergotamine

R1 = H, R2 =CH3, R3 = Benzyl
Activity and structure activity relationship

The lysergic- amide alkaloids are of medicinal and
toxicological importance, always the (l) forms (lysergic acid
derivatives) are physiologically active while the (d) isomers
(isolysergic acid derivatives) are inactive.

Ergometrine is the most active, concerning the oxytocic and

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