Page 87 - Phytochemistry 2 (06-PG 605)
P. 87
R CO-NH-R
H N CH3
HO
H
N
H
The C9-C10 double bond is easily hydrogenated, by catalytic
reduction, to give dihydroderivatives. Dihydro-ergot alkaloids
(e.g.dihydroergotamine) are utilized therapeutically for the
treatment of migraine, but they lose their ecbolic or oxytocic
properties.
Uses
Ergotamine is mainly used as analgesic in migraine as it
constricts the peripheral blood vessels.
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