Page 64 - Biochemistry2 (08PB403)
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2) Inhibitors of ATP/ADP Translocation
& ATP Synthesis.
a) Atractyloside: (from Actractylis gummifera)
inhibits transport of ADP/ATP translocase (Antiport)
of the inner mitochondrial membrane. (inhibits influx
of ADP).
b) Bongkrekik acid:
inhibits ADP/ATP translocase (Antiport) of the inner
mitochondrial membrane. (inhibits efflux of ATP).
c) Oligomycin:
inhibits ATP synthetase (complex V), thus inhibits
phosphorylation of ADP to ATP. 65
