Page 91 - Biochemistry2 (08PB403)
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Clinical Aspects of Glycolysis
1- Pyruvate kinase deficiency:
• This leads to excessive hemolysis of RBCs leading to
hemolytic anemia.
• Genetic deficiency of PK leads to decrease in rate of
glycolysis and decrease production of ATP. ATP is
required for Na-K ATPase which is important for the
stability of RBCs.
2- Hexokinase deficiency:
• Similar mechanism as PK
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