Page 92 - Biochemistry2 (08PB403)
P. 92

3-Lactic acidosis:

• It is the lowered blood pH and bicarbonate levels due
   to increased blood lactate above normal. This
   depletes bicarbonates decreasing pH of blood leading
   to lactic acidosis which may be severe and cause
   coma.

     OH
CH3-C-COOH + NaHCO3 ----►CH3-C-COONa + H2CO3 ------► CO2 + H2O

• Causes:
    – Increased formation of lactate as in severe
       muscular exercise.

                                                                                                                                    91
   87   88   89   90   91   92   93   94   95   96   97