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Some additives lower its melting point e.g. volatile oil, chlorhydrate, methyl paraben, phenol,
and camphor.
Sometimes solidifying agents like cetyl ester wax (20%), or beeswax (4%) may be melted with
the cocoa butter to compensate for the softening effect of the added substance.
b) Semisynthetic glycerides.
❖ Glyceryl monostearate and glyceryl monopalmitate
❖ Witepsol bases (triglycerides of saturated fatty acid .W-H 15, W-H25, W-H55.
❖ Wecobee base (triglyceride derived from coconut oil).
❖ Fattibase (triglycerides from palm oil, and coconut oil with self-emulsifying glyceryl

monostearate and polyoxylstearate).
Advantages of semi-synthetic glycerides:

• No polymorphism
• Tolerance of oxidation
• Rapid solidification
II. Gelato-glycerin base
Rectal gelatoglycerin suppositories are prepared according to the following ratios:
❖ USP: glycerin 70%, gelatin 20%, water 10%
❖ BP: glycerin 70%, gelatin 14%, water 16%
There are two types of gelatin:
❖ Gelatin A for acidic / cation drug.
❖ Gelatin B for basic / anion drug.
Urethral suppositories are prepared according to the following ratio: glycerin 20%, 60% gelatin,
and 20% medicated aqueous portion.
Urethral gelatoglycerin is preferred over cocoa butter which is brittle and rapidly softens.
Properties of gelatoglycerin base

❖ Laxative properties.
❖ Hygroscopic.
❖ Overheat releases toxic volatile material.
Suppositories made with glycerinated gelatin must be kept in well-closed containers in a cool place
since they will absorb and dissolve in atmospheric moisture.
Suppositories may have a dehydrating effect and be irritating to the tissues upon insertion. The
water present in the formula of suppositories minimizes this action.

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