Page 100 - phytochemistry II -pharmD general
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Methods of Assay (estimation)
❑ Colorimetric method
❑ Spectrophotometric method.
Pharmacological effects & uses:
• Pilocarpine is a non-selective muscarinic receptor agonist in the parasympathetic
nervous system.
• Pilocarpine action being antagonistic to that of atropine.
In ophthalmology:
1. It reduces the possibility of glare at night from lights, after refractive surgery and
after intraocular lenses implantation.
2. It acts on a subtype of muscarinic receptor found on the iris sphincter muscle,
causing the muscle to contract and produce miosis; thus treating acute angle-
closure glaucoma.
3. It also acts on the ciliary muscle, causing widening of the trabecular meshwork
spaces. This action facilitates aqueous humor drainage to decrease intraocular
pressure. Thus, treating chronic open-angle glaucoma (chronic simple
glaucoma).
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