Page 99 - phytochemistry II -pharmD general

➢ Stability:

▪ 1-The lactone ring is opened by heating with caustic alkali
The opening of the lactone ring destroys the physiological activity of pilocarpine.

CH3- CH2 H CH2
O O
N - CH3
N

H CH2
CH3- CH2
N - CH3
O N
OH HO

Pilocarpic acid

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