Page 104 - phytochemistry II -pharmD general
P. 104
OH
E
N
CD
AB
HO
Typical Steroidal Structure (Rubijervine)
E N
CD
AB HO
HO
Atypical Steroidal Alkaloid (Veratramine)
(C-nor, D-homo Steroidal Structure)
II)- The second type:
Include ester alkaloids derived from highly hydroxylated alkamines of
atypical C-Nor D-homo steroidal ring system. The hydroxyl groups of the basic
alkamine structure are esterified by one to four molecules of the organic acid.
Acetic, -methylbuteric, angelic, tiglic, vanillic and veratric.
Examples of ester alkaloids of the second type are protoveratrine A&B, cevadine,
cevacine and veratridine. The alkaloid protoveratrine A is the 3,6,7,15 tetraester
of the alkamine protoverine.
N
OH
O5 OH
HO OH
OH
OH
OH OH
Protoveratrine A Protoverine
(Steroid ester alkaloid of second type)
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