Page 48 - phytochemistry II -pharmD general
P. 48
Test for identification
1-Warren’s test for papaverine:
Few crystals of papaverine are crushed with crystal of potassium permenganate
and one drop of Marqui’s reagent. A green colour develops, rapidly changed to
blue.
Assay : By non aqueous titration.
Uses
• Papaverine possesses spasmolytic (smooth muscle relaxant ) and
vasodilator activity.
• It is used as antispasmodic for GIT spasms and in bronchial asthma in a
dose up to 600 mg of papaverine HCL daily.
Noscapine C(N2a2rHco2t3inNeO) 7 413.4
O
O NMe
MeO H
MeO H
O
MeO Lactone ring
O
Properties
❖ It is a laevorotatory, very weakly basic alkaloid
❖ Practically insoluble in water
❖ Containing a lactone ring.
❖ Hot alkali hydroxide opening of lactone ring.
❖ Being a weak base, it can be extracted from aqueous acid solution with
chloroform.
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