Page 20 - Pharmaceutics III_ 02-06-01304_Fall 2025_ Pharm D_Electronic book
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Discuss the relationship between bulkiness, particle size, and powder handling.
Guide points: Define bulkiness, relate it inversely to bulk density, and explain with examples
how particle size and adhesion influence powder flow and container requirements.
Explain how powder flow properties are assessed and how they relate to
pharmaceutical processing.
Guide points: Describe the measurement and interpretation of angle of repose, bulk/tapped
density, Hausner ratio, and Carr’s index. Discuss implications for capsule filling and tablet
compression.
Discuss how micromeritics principles are applied in optimizing dosage form design.
Guide points: Provide examples of how controlling particle size and distribution improves
dissolution (micronized drugs), suspension stability, aerosol deposition, and topical product
smoothness.
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