Page 61 - Pharmaceutics III_ 02-06-01304_Fall 2025_ Pharm D_Electronic book

Problem Possible Cause Corrective Action

Pellets breakage Over-compression Reduce tamping pressure

Health and Safety Precautions:
• Use dust extraction and exhaust hoods.
• Wear gloves, masks, goggles.
• Avoid inhalation of fine powders.
• Regular cleaning to prevent dust explosions.

Industrial Scale-Up Considerations:
• Powder flow and compressibility behavior must be maintained.
• Similar granulation moisture and density as pilot batches.
• Compression force and dwell time optimized.
• Equipment scaling parameters (tip speed, pan load) adjusted proportionally.

Troubleshooting Tableting Problems:

Defect Likely Cause Solution

Sticking Moist granules, too much binder Dry properly, polish punches

Picking Sticky active ingredient Use anti-adherents

Capping Air entrapment Reduce speed, adjust moisture

Mottling Uneven dye distribution Use lake pigments

Weight variation Poor flow Add glidant

Hardness variation Pressure fluctuation Regulate compression

Tablet Coating Defects and Remedies:

Defect Description Cause Remedy

Picking Film removed by sticking Over-wetting Reduce spray rate

Peeling Film separates from core Poor adhesion Increase polymer
concentration

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