Page 63 - Pharmaceutics III_ 02-06-01304_Fall 2025_ Pharm D_Electronic book
P. 63
• Lubricant blending time optimized (< 5 min).
• Moisture content standardized.
In-Process Tests During Compression:
• Appearance.
• Average weight.
• Thickness.
• Hardness.
• Disintegration.
• Ejection force (machine reading).
Coating Parameters (Industrial):
• Pan speed: 6 – 15 rpm.
• Inlet air temperature: 40 – 60 °C.
• Spray rate: 10 – 20 mL/min (lab scale).
• Atomizing pressure: 1.5 – 3 bar.
• Relative humidity: < 50 %.
Film-Forming Polymers (Summary):
Type Example Solubility Use
Cellulose derivatives HPMC, HPC, EC Water/organic Film former
Methacrylate polymers Eudragit E, L, S pH-dependent Enteric or SR
Vinyl polymers PVP, PVAc Water/ethanol Adhesion
Acrylic dispersions Kollicoat SR 30D Aqueous SR coating
Plasticizers: PEG 400, PEG 6000, triethyl citrate, castor oil, propylene glycol.
Used 1–30 % w/w of polymer to improve film flexibility.
Colorants and Opacifiers:
• Iron oxide pigments, titanium dioxide.
• Lake colors (dye adsorbed on Al(OH)₃).
62
