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alpha-pinene, beta-pinene , cineole, and betacaryophyllene,
- Flavonoids: including casticin, eupatorin and penduletin; together with

other flavonoids as vitexin and orientin.
- Iridoid glycosides: including aucubin and agnuside
- Diterpenes: including rotundifuran, vitexilactone, and vitetrifolin B.
Uses:
Effects on Female genital disorders: Normalizes the menstrual cycle,
encourages ovulation. Indicated for any kind of premenstrual syndrome
(PMS) problems (resulting from corpus luteum deficiency and the relative
progesterone deficiency).
It is also used for menopause syndromes.
Its mechanism of action is:
Enhances corpus luteal development (thereby correcting a relative
progesterone deficiency:
- Vitex extract has dopaminergic activity on the anterior pituitary (which
inhibits prolactin)& normalizes hormone levels. The dopaminergic action by
binding to D2-receptors.

Uses Approved by Commission E:
• Premenstrual syndrome (PMS)
• Menopausal complaints
Clinical studies:
Clinical studies found that vitex can be used for the treatment of menstrual
problems, premenstrual syndrome particularly indicated for patients with
deficient corpus luteum function (corpus luteum insufficiency).

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