Page 12 - Dosage 1-part2 -ebook

30/10/2025, 00:02 Pharmaceutical Solutions & Sterile Dosage Forms

Potable (drinking or tab) water

It is not normally used for the manufacture of pharmaceutical solutions or for extemporaneous
compounding as it contains dissolved substances which could interfere with the formulation
(reduce drug solubility and stability).

Tap water is therefore purified, by distillation, ion exchange (deionized) or reverse osmosis to
produce purified water.

Types of water used in pharmaceutical
formulations:

1. Purified water

It is prepared from suitable potable water by distillation (distilled water), ion-exchange
materials (deionized water), or reverse osmosis.

Q: What is the difference between distilled and deionized water !!?

2. Water for injection

is pyrogen-free distilled water, sterilized immediately after collection.
Pyrogens are water-soluble, fever producing compounds.

What about water used in compounded oral or external solutions prepared in the
pharmacy?
In extemporaneous dispensing, drinking tap (potable) water, freshly drawn from mains
supply, boiled and cooled, can be used to prepare oral or external solutions that are not
intended to be sterile.

Q: HOW to improve/modify aqueous solubility of solid drugs !? 9/77

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