Page 16 - Pharmaceutics IV (02-06-01305)
P. 16

Parenterals: Routes  Intravenous (IV)

    Why infusions?

    The problem with infusion is it takes a few hours to achieve a steady
    state. It is often best to start with a bolus injection to cover the first few
    hours before the infusion achieves its steady level.

25

    Parenterals: Routes  Intravenous (IV)

    Why infusions?

    • By altering the infusion rate, it is possible to titrate the dose against
       the effect required, e.g. controlling blood pressure

    • Slow IV infusion of a drug product is useful to avoid side effects,
       such as chemotherapeutic agents for cancer therapy.

      26                                                                            13

Salma E. EL-Habashy
   11   12   13   14   15   16   17   18   19   20   21