Page 218 - Pharmaceutics IV (02-06-01305)
P. 218
30/03/2024
Its surface is coated with a continuous thin layer of
mucus produced by sub-epithelial mucous glands.
The ciliated epithelium of the nasal passage facilitates
the movement of the mucous layer.
The mucus contains lysozyme, glycoproteins, and
immunoglobulins that act against bacteria and protect
against their entry into the lungs.
The ciliary action and the sneeze reflex add further
defense against entry .
Dr ALyaa Ramadan, AU 11
11
Drugs introduced into the nasal passage are primarily for local
effects on the mucous membranes and underlying tissues (e.g.,
nasal decongestants).
In conventional therapy, nasal medication is used for the
treatment of minor local diseases such as nasal pain, nasal
congestion, nasal infections, and allergic or chronic rhino
sinusitis.
However, drug absorption to the general circulation does occur
through the rich blood supply feeding the nasal lining…….next
Dr ALyaa Ramadan, AU 12
12
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