Page 279 - Pharmaceutics IV (02-06-01305)

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Quality control tests for MDI

Delivered dose per actuation, number of metered doses, color,
particle size distribution, loss of propellant, pressure, valve
corrosion, spray pattern, and absence of pathogenic
microorganisms.
So Analysis of dose uniformity , particle size distribution pat-
terns , and the respirable fractions of aerosol-delivered particles
are areas of research in developing aerosol products for optimal
oral inhalation therapy.

the influence of the aerosol form of the drug on the recipient tissue
membranes must be evaluated for irritating effects and changes in the

absorptionProoffAtlhyaea dRarmuagdafnr,ocemutictsh, eAUsite of application
65

Conclusion

Understanding physicochemical particle
properties is paramount for designing efficient

and robust inhalation products.

Prof Alyaa Ramadan, ceutics, AU

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