Page 277 - Pharmaceutics IV (02-06-01305)

Device factors affecting 3/30/24
pulmonary drug delivery 31

Efficiency of Size uniformity of location of spray
spray, size sprayed droplets, generation in the

context of
patient’s anatomy,

width of spray the speed of the
zone, and aerosol.

Prof Alyaa Ramadan, ceutics, AU

61

Choice of devices

the Drug (such as solubility and stability in aqueous medium),
The formulation (e.g., Dry powder or aqueous solution),
Pathophysiology of the lungs (e.G., Lung capacity),
The status of the patient (e.g., in patient or ambulatory self-use)

• Coordination of inspiration time with device actuation (pressurized)
• The strength, quantity, and consistency of air intake for breath-actuated

devices. (non-pressurized)

Prof Alyaa Ramadan, ceutics, AU

62