Page 273 - Pharmaceutics IV (02-06-01305)

3/30/24

Nebulizer formulation

All nebulizers require a solution or suspension-based formulation,
which places stringent demands on the solubility and stability of the
drug in aqueous media
For protein and peptide drugs, the stability of proteins and peptides
upon shearing can pose additional limitation. Nebulization exerts high
shear stress on these macromolecules, which can lead to their
denaturation.
The physical properties of drug solutions (e.g., ionic strength,
viscosity, osmolarity, pH, and surface tension) may change with dosing
and may affect the nebulization efficiency.

Prof Alyaa Ramadan, ceutics, AU

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New types of nebulisers

New generation of nebulizers: (A) AERx (Aradigm), (B) Respimat (Boehringer),
(ultrasonic) generate an aerosol mechanically and reduce the shear forces on
the drug
(C) AeroDose (AeroGen Inc). vibrating mesh technologies (membrane)

significant disadvantage of devices of this type is the high cost,
which is an obstacle to theirPwrofidAelysapa Rreamadadauns, ceeutics, AU

54

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