Page 274 - Pharmaceutics IV (02-06-01305)

Design elements of drug delivery systems 3/30/24
to increase absorption through lung 28

Size and drug loading of the particles:

• Aerodynamic diameter and size distribution of the particles need to be carefully controlled to
maximize particle deposition in the alveoli. …next slides

Density of the particles :

• impacts diffusivity of the drug

Particle shape :

• Ideal particle shape for pulmonary drug delivery is spherical.

Aggregation :

• controlled by surface charge and characteristics)

Hygroscopicity

• idealy decrease hygroscopicity to decrease adhesion and optimize deposition

Prof Alyaa Ramadan, ceutics, AU

55

Formulation considerations important for the
development of aerosol dosage forms

Uniformity of drug content, especially in the case of powders and suspension;
Particle size and size distribution, shape, and density (for powders and
suspensions);
Flow through the nozzle,

Compatibility with the container components,

Emitted dose, and

Fine particle dose or fine particle fraction in the emitted dose.

Prof Alyaa Ramadan, ceutics, AU

56