Page 269 - Pharmaceutics IV (02-06-01305)

3/30/24

DPI types

Multi-dose Turbohaler
Diskhaler
Powder inhalation
(non_pressurized) Diskus
Rotahaler
capsule-based Single- Spinhaler
devices dose

Prof Alyaa Ramadan, ceutics, AU

45

Single or unit dose DPI

The dry powder formulation is filled and provided in a hard gelatin
capsule.
The device pierces the capsule and provides inspiratory air pathway that
would fluidize the capsule and would enable release of its contents
through the piercing.
The drug particles form an aerosol in the inspired air upon breathing by
the patient
For stability reasons, unit-dose devices are preferred for protein delivery

Prof Alyaa Ramadan, ceutics, AU

46

23