Page 265 - Pharmaceutics IV (02-06-01305)

3/30/24

Challenges associated with using MDI

High velocity of the generated aerosol spray causes
substantial oropharyngeal deposition by impaction,
which results in poor drug delivery to the lung.

qBronchospasm may be due to:

– The propellants in the MDI(CFC)
– Benzalkonium chloride preservative

Prof Alyaa Ramadan, ceutics, AU

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How to overcome?

qThe patient may be advised to

– Switch to dry powder inhalers…next slides
– Switch to a hydrofluoroalkane metered-dose inhaler.
– Use a spacer (Role?)

ü It reduces aerosol velocity.
ü It overcomes difficulties in the coordination of inhalation and

actuation, especially for pediatric patients, resulting in improved
dosing reproducibility.

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Prof Alyaa Ramadan, ceutics, AU

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