Page 262 - Pharmaceutics IV (02-06-01305)

3/30/24

About MDI..

MDIs generate aerosol for inhalation by expelling a measured
dose of pressurized liquid propellant containing drug via an
orifice.
They are portable, easy to use, and the most commonly used
inhalation aerosol devices today
Drug solubility, vapor pressure, surface tension, solubility of
oxygen/hygroscopicity, and density affect the effectiveness of
drug delivery through the MDIs.(important)
MDIs are commonly used for the delivery of drugs for asthma
and chronic obstructive pulmonary diseases (COPD).

Prof Alyaa Ramadan, ceutics, AU

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Factors affecting MDI efficiency

PATIENT’S BREATHING HAND–MOUTH
INSPIRATORY PATTERN COORDINATION.
FLOW RATE,

(Increase in tidal volume Most patients need to
(volume of air moved into or out be trained for proper

of the lungs during normal use of the MDI.
breathing) and decrease in (community course)
respiratory frequency increase
peripheral drug deposition in the

lung. )

Prof Alyaa Ramadan, ceutics, AU

32

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