Page 266 - Pharmaceutics IV (02-06-01305)
P. 266
3/30/24
Non-pressurized aerosols
The dry powder inhaler (DPI) allows the drug to be formulated in dry state,
in which it may be more stable, does not require the use of a liquid propellant,
and also does not require patient coordination between breathing and actuation.
DPIs consist of a suspension of fine particulate drug formulation, which is
dispersed by mechanical, pneumatic, or electrical energy, or by the strength of
the vacuum generated by the patient’s breathing.
DPIs generate aerosols by drawing air through the loose dry powder of a drug
formulation.
DPIs have been used to treat diseases such as asthma, bronchitis, emphysema,
and COPD And protein delivery to the lungs
Prof Alyaa Ramadan, ceutics, AU
39
Non-pressurized aerosols
• The dry powder inhaler (DPI) allows the drug to be formulated in dry state, in which
it may be more stable, does not require the use of a liquid propellant, and also does not
require patient coordination between breathing and actuation.
• DPIs consist of a suspension of fine particulate drug formulation, which is dispersed
by mechanical, pneumatic, or electrical energy, or by the strength of the vacuum
generated by the patient’s breathing.
• DPIs generate aerosols by drawing air through the loose dry powder of a drug
formulation.
• DPIs have been used to treat diseases such as asthma, bronchitis, emphysema, and
COPD. And protein delivery to the lungs
Prof Alyaa Ramadan, ceutics, AU
40
20
