Page 37 - Pharmaceutics IV (02-06-01305)
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Pharmaceutical requirements

                      Absence of pyrogens

  Depyrogenation: dry heat

  • Endotoxins can be destroyed by dry heat (250°C for 45 min, for 650°C
      for 1 min or 180°C for 4 hr) for:
      ➢ Glassware and containers
      ➢ A product from nonsterile starting material that can withstand the
          heat of 200°C

67

                     Depyrogenation: other methods

   • Ultrafiltration
   • Reverse osmosis
   • Adsorption

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Salma E. EL-Habashy
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