Page 41 - Pharmaceutics IV (02-06-01305)
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Pharmaceutical requirements  Isotonicity

    Pharmaceutically

    • Intravenous infusions (LVP) should be made isotonic with human
       plasma.

    • CNS (Intrathecal, epidural or intracisernal), intraarticular and
       intraocular injections should also be isotonic to avoid serious
       changes in osmotic pressure in sensitive tissues.

    • It is considered desirable for subcutaneous, intradermal and
       intramuscular injections also to be isotonic to minimize local
       irritation.

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                                 Clarity

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Salma E. EL-Habashy
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