Page 43 - Pharmaceutics IV (02-06-01305)
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Pharmaceutical requirements

                      Clarity (for solutions)

  Source & contaminants

  • Contaminants include dust, cloth fibers,
      glass fragments, material leached from the
      glass or plastic container or seal.

  • Sources of particulate matter include the
      raw materials, processing and filling
      equipment, the container, and
      environmental contamination.

79

  Pharmaceutical requirements

                      Clarity (for solutions)

  Complications

  • IV: pulmonary embolism
  • IV: infusion phlebitis
  It has been shown that the development of infusion phlebitis (vein
  inflammation) may be related to the presence of particulate matter in
  intravenous fluids.
  • IM: injection granuloma/muscle granuloma

      80                                                                 40

Salma E. EL-Habashy
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