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Pharmaceutical requirements
Clarity (for solutions)
• Clarity is defined as the state or quality of being clear or transparent
to the eye. Particles of approximately 50 μm may be detected in this
manner. Reflective particles, such as fragments of glass, may be
visualized in smaller size, about 25 μm.
• Particulate matter is defined in the USP as extraneous, mobile,
undissolved substances, other than gas bubbles, unintentionally
present in parenteral solutions.
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Pharmaceutical requirements
Clarity (for solutions)
• One of the prime requisites of parenteral solutions is clarity.
• They should be sparkling clear and free of all particulate matter.
• They must be free of visible particles and contain only very low
numbers of sub-visible particles.
• This is of particular importance for medicines administered
intravenously.
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Salma E. EL-Habashy
