Page 89 - Pharmaceutics IV (02-06-01305)
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Parenterals: Quality control testing
Foreign and particulate matter/ clarity testing
Sub-visible particulates (particle count)
• The light-obscuration method uses
an electronic instrument designed to
count and measure the size of particles
by means of a shadow cast by the
particle as it passes through a high-
intensity light beam
171
Parenterals: Quality control testing
Foreign and particulate matter/ clarity testing
Sub-visible particulates (particle count)
• The microscopic method is conducted by filtering a measured
sample of solution through a membrane filter under ultraclean
conditions and then counting the particles on the surface of the
filter, using a microscope.
172 86
Salma E. EL-Habashy
