Page 138 - Pharm.Org.Chem-I 02-06-05-101
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Summary of SN2 reaction
❑ The reaction is effective with methyl> primary >
secondary alkyl halides only.
❑ It occurs stereospecifically with inversion of
configuration at a stereocenter.
❑ Use of alkyl iodides and bromides is preferable, but
alkyl chlorides will react slowly.
❑ It is a second order reaction whose rate is affected by
the concentration of the alkyl halide and the
nucleophilic reagent.
❑ Stronger nucleophiles are more effective than weak
nucleophiles.
Useful links
• https://www.youtube.com/watch?v=h5xvaP6bIZI
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