Page 139 - Pharm.Org.Chem-I 02-06-05-101

From Alkyne lecture: in synthesis of alkynes

• Higher alkynes are synthesized by alkylation of
acetylene or terminal alkynes.

• Removal of the acidic hydrogen of terminal alkyne
using sodamide in liquid ammonia followed by
reaction with primary alkyl halides ONLY. (NEXT
LECT.)

Unimolecular nucleophilic substitution
reaction (SN1) mainly for 3o alkyl halide

Step 1:

Step 2:

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