Page 179 - Biochemistry PharmD General
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Type-V (McArdle’s Disease)
• It is caused by the deficiency of muscle
phosphorylase (responsible for glycogenolysis).
• Glycogen accumulates in skeletal muscle in large
amounts.
• It results in muscle cramps and muscle damage, as
glycogen cannot be utilized as an energy supply due to
lack of phosphorylase.
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