Page 55 - Dosage 1-part2 -ebook_Neat

30/10/2025, 00:02 Pharmaceutical Solutions & Sterile Dosage Forms

Hypotonic parenteral solutions

IV injection cause Haemolysis of RBC which is Irreversible & Fatal.

Thus, they are made isotonic by addition of electrolytes as sodium chloride or osmotic agents as
mannitol or glucose.

NOTE: Osmotic agents as mannitol or glucose are incompatible with drugs.
Solutions are made isotonic with isotonic saline solution (0.9% NaCl)

Components of parenteral products:

1. Container (packaging). Vials
2. Active constituent.
3. Solvent. Single dose or Multi-dose SVP (1-100 mL)
4. Additives (Excipients).
Glass bottles with rubber cap and sealed with
1. Container (packaging) an aluminium seal covered with a plastic
cover.
Ampoules
Self-seal of rubber after needle withdrawal.
Single dose glass container for SVP
The glass neck should be scratched (or self- Rubber material may be natural or synthetic
breaking). (butyl rubber).
Disadvantages:
Disadvantages:
As ampoules may release some glass
particles into the solution, it has to be Incomplete sealing of multi-dose
filled under vacuum. Air contamination
Release of rubber particles
file:///C:/Users/sara talaat/Downloads/solutions and sterile sols.HTML Adsorption of injection components
(preservatives)

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