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• Serious burns may result from exposure to UV-A light or sunlight, even through
glass, if the correct dose is not followed.

• Avoid the ingestion of foods that contain furano-coumarins, such as limes, figs,
parsley, celery, cloves, lemons, mustard and carrots.

Precautions:
Drug interactions:

The toxicity of Ammi majus fruits may be increased when the fruits are administered with
other photosensitizing agents such as coal tar, griseofulvin,nalidixic acid,phenothiazines,
sulfanilamides, tetra-cyclines and thiazides.

Dosage forms:
As powdered dried fruits for oral use.
Store in a tightly sealed container away from heat and light.

Posology:
(Unless otherwise indicated)

Average daily dose: Ammi majus fruits (0.02-0.04 g) orally in divided doses (dosage
schedule not specified).

Xanthotoxin: 0.25-0.7 mg/kg bw.

5- Hemlock (Fructus Conii)

Hemlock (Conium) is the dried unripe fruits of Conium maculatum L.

It is poisonous plant indigenous to Britain and Europe and was used by the Greeks for
preparing a draught by means of which criminals were put to death.

Description:

The fruit is grayish-green in colour, broadly ovoid and slightly laterally compressed, about
3 mm long and bears a small stylopod with the remains of the stigma. Each mericarp has
5 paler prominent primary ridges which are irregularly enlarged at intervals giving them a
wavy appearance. There are no conspicuous vittae in the mesocarp.

The endocarp is developed as a well-defined dark layer of brown cells containing
alkaloids and called coniine layer.

The seed: is campylospermous.

Constituents:

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