Page 90 - phytochemistry I - PharmD Clinical

2. Preparation from the glycoside coniferin by oxidation.

3. Vanillin is prepared commercially in large amount from guaiacol
(catechol methyl ether) by the Reimer-Tiemann's reaction).

4. Commercial method by oxidation of lignin, which is a by-product in
manufacture of paper. lignin is a complex polymeric structural
material of woody plants and contains as a structural unit, the
fragment

Upon oxidation of lignin, vanillin is formed in a high yield to make the
process economically feasible.

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