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G-6-PD deficiency

• Inherited disease-most common disease producing
   enzyme abnormality in humans- X-linked.

• People with glucose 6-phosphate dehydrogenase
   deficiency (7% of the world population).

• Hemolytic anemia due to inability to detoxify
   oxidizing agents.

• ↓activity of G6-PD→↓NADPH            [HMP]
   →↓detoxification of FR & peroxides

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