Page 134 - BIOCHEMISTRY II

Mechanism

Normally, RBCs HMP shunt provides NADPH + H+ for
reduction of oxidized glutathione
(G-SS-G) to reduced glutathione (2 GSH) catalyzed by
glutathione reductase.

Glutathione
G-SS-G + NADPH + H+ -------------- 2 G-SH + NADP+

reductase

133