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Limitations: Figure 22: OroQuick HCV antibody
Delayed sero-conversion
Immuno-compromised, and dialysis patients may
remain sero-negative
HCV nucleic acid testing: qualitative vs quantitative
Qualitative: PCR
• Viraemia in sero positives
• Blood products
RNA dynamics:
• 8-10 days post infection
• Intermittently positive before Challenge for blood safety
Figure 23: RNA dynamics
Glynn et al., 2005 Transfusion
