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Clinical utility:
Previous failure of DAA containing regimen
Targetted testing for particular RAVs in patients with specific genotypes
Next generation sequencing:
Figure 26: Next generation sequencing
• Simultaneous sequencing of millions of targets
• Whole genomes
• Quasispecies
• Relative abundance of particular SNPs
• Even minor populations
• Clinical significance of minor populations?
Improving point of care diagnostics
Most HBV and HCV infected individuals are unaware of their status
Figure 27: Improving point of care diagnostics
Viral nucleic acid Isothermal Naked eye detection
amplification
RNA or DNA Robust
Simple equipment
Tolerates inhibitors
Masses of product
