Page 137 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

Antiviral drug

Clinical classification

A. Anti-herpesvirus Agents

B. Anti-influenza Agents, RSV

C. Anti-hepatitis Agents

D. Antiretroviral Agents

B. Anti-herpesvirus Agents

Acyclovir

Prodrug valaciclovir is converted to acyclovir in vivo

only effective when it is phosphorylated in the cell by viral thymidine kinase
human cell DNA synthesis is little affected
Nucleoside analogues, inhibit viral DNA polymerase and incorporated in viral
DNA and cause premature termination of DNA synthesis.

Uses: treatment of infection by
➢ Herpes simplex Varicella zoster

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